Arsenal and Manchester United will look to take a leaf out of the book of Chelsea and Liverpool and book safe passage to the quarter finals of the Champions League.
Chelsea were pushed to the limit by Juventus, Liverpool were not by Real Madrid, and it is likely that The Gunners and The Red Devils will have to be at the top of their game.
United welcome Inter to Old Trafford with the tie delicately poised following a 0-0 draw in the first leg at the Giuseppe Meazza.
Arsenal head to the Eternal City protecting a 1-0 lead from the first leg, when they dominated Roma but failed to convert a glut of chances.
The two other games on Wednesday are also on a knife edge, with Barcelona hosting Lyon having claimed a 1-1 draw in France and Atletico Madrid travelling to Porto with their game level at 2-2.
All the preview news for the four games can be found by clicking on the individual links below.