The 'Ides of March' actor injured himself while filming spy thriller 'Syriana' in 2005, and he was so racked with pain as a result of the spinal condition that he thought about ending his life.
He told Rolling Stone magazine: "I started to think, 'I may have to do something drastic about this.'"
"I was in a hospital bed unable to move, having these headaches where it feels like you're having a stroke.
"You don’t want to leave a mess, so go in the garage, go in the car, start the engine. I was in a place where I was trying to figure out how to survive."
The 50-year-old actor - who is dating former wrestler Stacy Keibler – also spoke about losing his virginity "too young" at the age of 16, and admitted he thinks he had his first orgasm when he was "six or seven" years old.
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He told said: "I was young, very young, too young.
"I believe it [my first orgasm] was while climbing a rope when I was six or seven years old. I mean, nothing came out, but all the other elements were there. I remember getting to the top of the rope, hanging off the rope, and going, 'Oh, my God, this feels great!' "