Clooney - who's half Irish - says he's glad he's not competing with Robert Pattinson for movie roles.
Clooney, 48, reckons Pattinson, 23, is one of the best looking men in Hollywood.
“Thank God I don’t have to compete with Rob,” Clooney said. “He’s young and handsome and talented.”
Pattinson - who Clooney calls "Mr Handsome" recently autographed a copy of GQ and sent it down to Clooney "To George, Best of Luck. Hang in there. Love Rob."
What did Clooney do?
He sent back a copy of Esquire magazine, with the following message inscribed to Pattinson.
"Dear Rob, Thanks for all the inspiration. I'm a huge fan. Love, George, two-time Sexiest Man Alive.”