The 50-year-old surgeon's 1995 Jeep Wrangler when off the side of the Pacific Coast Highway and landed on its roof according to the California Highway Patrol.
Apart from Heidi Montag, star of "The Hills", Ryan's other celebrity patients included musician Vince Neil, actor Lorenzo Lamas, reality stars Lisa Gastineau and Adrianne Curry and several models and beauty queens.
Montag once underwent ten procedures in one day with Ryan. She tweeted in response to his death. She said "I am devastated…He was the most amazing person I have ever known. He was an angel and changed my life and the lives of everyone he met. He was the most brilliant talented surgeon who will ever exist. Dr. Frank Ryan changed the world."
Modeling agent, Janice Dickson, was a close friend of Ryan's. Her publicist said she was "deeply, deeply anguished" having heard about the accident. "She is stunned and wants the world to know what a genius Dr. Ryan was…Her love goes out to his mother and the rest of the family."