The writer says the next series of the musical TV show will be the last and he has revealed he had already penned the final scenes which would have featured Lea Michele and Cory Monteith - who were a couple in real life - playing on-screen lovers Rachel Berry and Finn Hudson.
Following Monteith's sad death in July from a heroin and alcohol overdose, Murphy has had to re-think the focus of the final series
Speaking at the Paley Center in Los Angeles at an event honouring the FX Network on Wednesday night Murphy said: "The final year of the show, which will be next year, was designed around Rachel and Finn's story.
"I always knew that, I always knew how it would end. I knew what the last shot was, he was in it. I knew what the last line was, she said it to him."
Like everyone associated with 'Glee,' Murphy is still in shock over Monteith's death at the age of just 31 and he admits he's yet to come up with a new storyline for the final run.
The 47-year-old screenwriter said: "When a tragedy like that happens you sort of have to pause and figure out what you want to do, so we're figuring that out now."
A special episode of 'Glee', titled 'The Quarterback,' was aired in tribute to Monteith and his character on October 10 with 7.4 million viewers tuning in.
The episode included a tear-jerking rendition of Bob Dylan's 'Make You Feel My Love' (video below), performed by Michele.