The actors are among 21 hunks to make AARP magazine's 'Men on Fire' list of older heartthrobs.
Other stars to make the cut include actors Viggo Mortensen, Liam Neeson and Samuel Jackson, rocker Jon Bon Jovi and Antonio Banderas.
When asked by the magazine whether he feels pressure to look younger, Antonio, 51, said: "No. Well, yes, I'm a little bald, but I don't think the pressure is just a Hollywood thing. It's a social thing.
"I work out every morning, and when I'm finished, the first thing I put in my body is white tea. Everything is about balance."
George was nominated not only for his looks, but also his philanthropic nature, while Denzel's 'Flight' co-star Don Cheadle thinks his friend's on-screen persona helps to project an image of him as a "grounded" star.
He said: "Denzel's mystique is that he projects self-confidence. You see his performances and know you're looking at a grounded person."
Other men on the list include cellist Yo Yo Ma, author John Irving and paleontologist Paul Sereno.
The magazine's editor-in-chief, Nancy Perry Graham, said: "Our readers understand that sex appeal is ageless, so we thought a feature on the sexiest men over 50 would be a great way to kick off summer."
AARP magazine, Men on Fire list 2012:
Jon Bon Jovi
Jon Huntsman Jr.
Robert F. Kennedy Jr.
Mario Van Peebles