Notre Dame's Fighting Irish will take on Army's Black Knights at new Yankee Stadium on November 20.
The two teams have a history of playing at the old Yankee Stadium, clashing 22 times at the house Babe Ruth built every year from 1925-46, bar 1930. The two teams also commemorated the 100th anniversary of college football in 1969 with a game at Yankee Stadium.
It is thought that NBC will air the game live.
"As a longtime Yankee fan, I'm thrilled to have the opportunity for Notre Dame to be a part of this event. I think this will be the kind of game that our players will remember long after it's over," said Charlie Weis, the Notre Dame football coach.
Notre Dame athletics director Jack Swarbrick is also delighted with the development and is looking forward to starting a new tradition.
"Any student of Notre Dame football history knows the meaning of the Notre Dame-Army rivalry and, in particular, the history of that rivalry at Yankee Stadium," he said.
"It's fitting that a Notre Dame-Army game will be the first football event in this fabulous facility - and it's also fitting that the 50th meeting in this great rivalry will take place in a venue with such great tradition for both programs."
The Irish enjoy a comfortable advantage in the previous 49 games with the Black Knights, leading 37-8-4, and also enjoy a strong Yankee Stadium lead, having gone 14-5-3 in the old home of the Yankees.
The Irish will also play another "home" game this season away from Notre Dame stadium when they entertain Washington State at the Alomodone in San Antonio on October 31.