The socialite lashed out after her sibling, Barron, was rushed to hospital in Miami, Florida on Friday night, hours after he was beaten up at a party and accused Lindsay, 27, of being responsible for the incident.
The hotel heir, 24, posted a picture of his wounded face on Instagram on Saturday and Paris commented: "They will both pay for what they did. No one f**ks with my family and gets away with it!!"
The blonde beauty, 32, also retweeted a message posted by her younger sister Nicky Hilton, 30, which reads: "Bad things happen when you hang out with bad people."
Barron has claimed he was assaulted while partying at a mansion, where the 'Mean Girls' actress is currently staying, in the early hours of Friday morning after the troubled actress accused him of talking about her behind her back.
He told police that Lindsay approached him at the party with a male friend and told him: "You talk s**t about me to my boyfriend, this is what you get."
He also said the actress was laughing as the unknown man then beat him up.
Lindsay and her father, Michael Lohan, have denied she was involved in the incident.
The 'Liz & Dick' star previously fell out with Paris in 2006 when society heir Brandon Davis launched a huge rant against Lindsay, egged on by the socialite and businesswoman.
Among other things, Brandon said of Lindsay: "I think she's worth about seven million [dollars], which means she's really poor. It's disgusting. She lives in a motel."