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Sen. Ted Kennedy died shortly before midnight Tuesday at his home in Hyannis Port, Mass., at age 77.
The man known as the "liberal lion of the Senate" had fought a more than year-long battle with brain cancer, and according to his son had lived longer with the disease than his doctors expected him to.
IrishCentral exclusively reported that Sen. Edward Kennedy had received the Last Rites from the Catholic Church on Tuesday as he began to lose his battle with the deadly cancer.
Sources close to the family confirmed that Kennedy, deeply religious like all the Kennedys, was anointed by a priest who administered the Sacrament to him at his bedside.
"We've lost the irreplaceable center of our family and joyous light in our lives, but the inspiration of his faith, optimism, and perseverance will live on in our hearts forever," the Kennedy family said in a statement.
"He loved this country and devoted his life to serving it."
Senator John McCain this week said the Senate was a tougher place without Kennedy.
"No person in that institution is indispensable," he said, "but Ted Kennedy comes as close to being indispensable as any individual I've ever known in the Senate because he had a unique way of sitting down with the parties at a table and making the right concessions."
McCain, who co-sponsored the ill-fated Kennedy/McCain immigration bill with Kennedy said the debate over health-care reform would likely be in a very different place today if Kennedy was present.
Sen. Edward Moore Kennedy was the youngest Kennedy brother who was left to head the family's political dynasty after his brothers President John F. Kennedy and Sen. Robert F. Kennedy were assassinated.
Kennedy championed health care reform, working wages and equal rights in his storied career.
In August, he was awarded the Presidential Medal of Freedom -- the nation's highest civilian honor -- by President Obama. His daughter, Kara Kennedy, accepted the award on his behalf.
Sen. Edward M. Kennedy, known as Ted or Teddy, was diagnosed with a malignant brain tumor in May 2008 and underwent a successful brain surgery soon after that. But his health continued to deteriorate, and Kennedy suffered a seizure while attending the luncheon following President Barack Obama's inauguration.
For Kennedy, the ascension of Obama was an important step toward realizing his goal of health care reform.
At the Democratic National Convention in August 2008, the Massachusetts Democrat promised, "I pledge to you that I will be there next January on the floor of the United States Senate when we begin the great test."
Sen. Kennedy made good on that pledge, but ultimately lost his battle with cancer.
Kennedy was first elected to the Senate in 1962, at the age of 30, and his tenure there would span four decades. A hardworking, well-liked politician who became the standard-bearer of his brothers' liberal causes, his career was clouded by allegations of personal immorality and accusations that his family's clout helped him avoid the consequences of an accident that left a young woman dead.