It is the penultimate weekend of the Premier League season and Manchester United need a point to wrap up a third successive title.
The champions entertain Arsenal in Saturday's early kick-off, keen to get the point to lift the trophy in front to their home fans.
Arsene Wenger's Gunners will be out to avenge their Champions League semi-final exit at the hands of United, with Andrei Arshavin available for the North Londoners.
The relegation issues take center stage at 3 p.m. with Middlesbrough desperate to beat Aston Villa, Newcastle United facing Fulham, and Hull City at Phil Brown's former club Bolton Wanderers.
Tottenham and Manchester City do battle as they compete for a Europa League place, while Stoke City meet Wigan Athletic and FA Cup finalists Everton tackle West Ham.
On Sunday, West Brom look to continue their brave battle against the seemingly inevitable drop when welcoming second-placed Liverpool to The Hawthorns before Chelsea take on Blackburn Rovers.
On Monday, Portsmouth and Sunderland will battle it out in a stay out of the relegation battle game.
Man United v Arsenal (12.45)
Bolton v Hull City
Everton v West Ham
Middlesbrough v Aston Villa
Newcastle v Fulham
Stoke v Wigan
Tottenham v Man City
West Brom v Liverpool (13.30)
Chelsea v Blackburn (16.00)