Relegation looms as large as Mike Ashley's rotund frame at Newcastle...will Arsenal add to their woes this weekend?
Only goal difference separates Newcastle from the relegation zone, but they can expect no favors from an Arsenal side that simply must keep winning in their pursuit of Champions League football.
All eyes will be on Craven Cottage too to see how Manchester United react to the battering they received against Liverpool. Will their title challenge continue to splutter at Fulham?
Liverpool themselves host Aston Villa in one of three Sunday kick-offs, with UEFA Cup-chasing Manchester City entertaining Sunderland while Hull wipe their shoes and head to Wigan.
Preceding that is Saturday's action, which see title hopefuls Chelsea travel to Spurs in a repeat of last year's 4-4 thriller, rock bottom West Brom host Bolton, top four-chasing Everton head to Portsmouth, struggling Blackburn welcome West Ham, and there is a relegation six-pointer as Middlesbrough meet Stoke.
Blackburn v West Ham
Fulham v Man Utd
Newcastle v Arsenal
Portsmouth v Everton
Stoke v Middlesbrough
Tottenham v Chelsea
West Brom v Bolton
Liverpool v Aston Villa
Man City v Sunderland
Wigan v Hull
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