He said: "I've always had really great friends on both sides of the aisle, so to speak.
"I grew up with strong women, my mom is strong and so is my sister and so was my aunt, Rosemary Clooney.
"I've always been comfortable around women. I have some truly great women friends and the friendship is non-romantic."
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The 'Syriana' actor values honesty and humor in his friends, and loves the way his loved ones keep him grounded.
He told Britain's HELLO! magazine: "I look for a sense of humor and fun, an interest in other people and, most important of all, honesty.
"I don't surround myself with people who are on my payroll and have to agree with every word I say.
"There's a lot of smooth talking around. But for every person who says to me, 'Wow, you were brilliant in that', there's a friend, or my mom, dad, or sister, rolling their eyes and going, 'Yeah George, you're really a genius.' That's very important to me."