The 'Anger Management' star hit out at Brooke Mueller - the mother of his four-year-old twin sons Bob and Max - following her failed attempt to secure a restraining order against him in court on Monday.
He posted on Twitter: "Oh, by the way, nice try this morning Brooke. You are a chubby weirdo who will lose at every turn trying to get between me and my boys (sic)"
Mueller - who left rehab last month - claimed in her petition for the restraining order that her ex-husband had threatened her life and stated she believes he is on a mission to sabotage her sobriety and could even plant drugs on her in his bid to keep her away from their sons, who are currently cared for by his ex-wife Denise Richards.
According to TMZ, the petition claims Sheen said: "There will be a reckoning. There will be a whirlwind. That they will all reap while desperate begging for my forgiveness. You've all been warned.
"I will exercise every resource at my disposal. I will, I will, I will, I will empty my entire war chest and if I can't get it done, I know a guy who can."
A follow-up hearing has been set for next month.
At the weekend, Richards - who has daughters Sam, nine, and Lola, eight, with Charlie, as well as her own two-year-old adopted daughter Eloise - was reportedly informed by the Los Angeles County Department of Children and Family Services (DCFS) that she was not allowed to take the children over to Sheen's house for a visit.
A source claimed that officials told the 42-year-old actress that they were annoyed with Sheen after he claimed his sons were in danger and were not being protected by the department after they were allowed an overnight stay with Brooke.
The 48-year-old actor blasted Mueller on Twitter as an "evil and pathetic uber loser" and slammed the DCFS as being "inept".