She wrote: “Drake has the ugliest smile, ugly gums uneven teeth ugly eyes,” before quickly deleting the tweet.
Amanda later added: “I won’t deny calling @drake ugly.”
Amanda, 27, recently lashed out at Drake's former fling Rihanna, saying her ex-boyfriend Chris Brown beat her because she is "not pretty enough".
The 'Easy A' actress launched a bitter attack on the 25-year-old 'Stay' singer, who was violently attacked by the 'Fine China' singer in 2009, and claims she almost named her dog Rihanna.
She tweeted: "Chris Brown beat you because you're not pretty enough," before adding: "@Rihanna no one wants to be your lover so you call everyone and their mother that I almost named my new dog Rihanna."
Rihanna, who recently ended her relationship with Chris and is said to be heartbroken that he appears to have rekindled his romance with his ex-girlfriend Karrueche Tran, hit back at Amanda, writing: "Ya see what happens when they cancel Intervention?," which only enraged the 'She's The Man' star further.
In tweets that have since been deleted, the actress responded: "@Rihanna unlike ur fugly faced self I don't do drugs! U need the intervention dog! I met ur ugly face in person! U aren't pretty u know it. (sic)"