\"Research

Research team leader Professor Dennis McCance Photo by: Queens University

Belfast scientists make major cancer treatment breakthrough

\"Research

Research team leader Professor Dennis McCance Photo by: Queens University

Scientists in Northern Ireland believe they have made a major breakthrough in the treatment of throat and cervical cancers.

The team based at Queen’s University in Belfast have claimed their research will lead to the development of new therapies to target non-cancerous cells surrounding a tumour, as well as the tumour itself.

The Newsletter newspaper reports that the Cancer Research and Cell Biology experts found the non-cancerous tissue, or ‘stroma’, surrounding cancers of the throat and cervix plays an important role in regulating the spread of cancer.

The report says they believe this opens the door for the development of new treatments targeting the non-cancerous tissue to help prevent it being invaded by neighbouring cancer cells.

Research team leader Professor Dennis McCance told the paper: “Cancer spreads as the result of two-way communication between the cancer cells in a tumour and the non-cancerous cells in the surrounding tissue.

“We already know that cancer cells are intrinsically programmed to invade neighbouring healthy tissue.

“But the cells in the non-cancerous tissue are also programmed to send messages to the cancer cells, actively encouraging them to invade.

“If these messages - sent from the healthy tissue to the tumour - can be switched-off, then the spread of the cancer will be inhibited.

“What we have discovered is that a particular protein in non-cancerous tissue has the ability to either open or close the communication pathway between the healthy tissue and the tumour.

“When the Retinoblastoma protein (Rb) in non-cancerous tissue is activated, this leads to a decrease in factors that encourage invasion by cancer cells. And so, the cancer doesn’t spread.”

The research findings were  published in the European Molecular Biology Organisation Journal.
Queen’s researchers said the Rb protein is found in both cancer and non-cancerous tissue, and that its importance in regulating the growth of cancer cells from within tumours is already well-documented.

This is the first time scientists have identified the role of the Rb found in healthy tissue, in encouraging or discouraging the spread of cancer.

The paper reports the research was conducted using three-dimensional tissue samples, grown in Professor McCance’s lab to replicate the stroma tissue found around cancers of the throat and cervix.

In relation to potential implications for cancer treatment, Professor McCance told the paper:

“Current treatments for cancer focus on targeting the tumour itself, in order to kill the cancer cells before they spread.

“This discovery opens the door for us to develop new treatments that would target the normal tissue surrounding a tumour, as opposed to the tumour itself.

“By specifically targeting pathways controlled by the Rb protein, it would be possible to switch off the messages that encourage cancer cells to invade, and inhibit the spread of the tumour.

“Our research has focused on cancers of the throat and cervix. But it is possible that Rb or other proteins in the healthy tissue surrounding other types of cancer, may play a similar role in regulating the spread of tumour cells.

“Therefore, the implications of this discovery could go far beyond throat and cervical cancer, and that is something we plan to investigate further.”

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