The two Irish-American actors will co-star in “Passion Play,” which tells the story of an “angel” whose life is ruled by a coldblooded gangster.
The “angel,” played by Fox, is a caged circus freak who has giant wings growing out of her back.
Rourke will play a down-on-his-luck trumpet player who becomes the angel’s savior.
When asked by MTV about the relationship between Fox and Rourke’s characters, the “Jennifer’s Body” star said: "There is a love story there – it’s clearly not going to be a typical one.”
The film, which is set for a 2010 release, will be Glazer’s directorial debut.